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Initiated by CREB: resolving gene regulatory programs in learning and memory: switch in cofactors and transcription regulators between memory consolidation and maintenance network

Kaldun, Jenifer C. ; Sprecher, Simon G.

In: BioEssays, 2019, vol. 41, no. 8, p. 1900045

Consolidation of long‐term memory is a highly and precisely regulated multistep process. The transcription regulator cAMP response element‐binding protein (CREB) plays a key role in initiating memory consolidation. With time processing, first the cofactors are changed and, secondly, CREB gets dispensable. This ultimately changes the expressed gene program to genes required to maintain the...