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Discrete cytosolic macromolecular BRAF complexes exhibit distinct activities and composition

Diedrich, Britta ; Rigbolt, Kristoffer TG ; Röring, Michael ; Herr, Ricarda ; Kaeser‐Pebernard, Stephanie ; Gretzmeier, Christine ; Murphy, Robert F ; Brummer, Tilman ; Dengjel, Jörn

In: The EMBO Journal, 2017, vol. 36, no. 5, p. 646–663

As a central element within the RAS/ERK pathway, the serine/threonine kinase BRAF plays a key role in development and homeostasis and represents the most frequently mutated kinase in tumors. Consequently, it has emerged as an important therapeutic target in various malignancies. Nevertheless, the BRAF activation cycle still raises many mechanistic questions as illustrated by the paradoxical...