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A bipartite butyrate-responsive element in the human calretinin (CALB2) promoter acts as a repressor in colon carcinoma cells but not in mesothelioma cells

Häner, Katrin ; Henzi, Thomas ; Pfefferli, Martine ; Künzli, Esther ; Salicio, Valerie ; Schwaller, Beat

In: Journal of Cellular Biochemistry, 2010, vol. 109, no. 3, p. 519-531

The short-chain fatty acid butyrate plays an essential role in colonic mucosa homeostasis through the capacity to block the cell cycle, regulate differentiation and to induce apoptosis. The beneficial effect of dietary fibers on preventing colon cancer is essentially mediated through butyrate, derived from luminal fermentation of fibers by intestinal bacteria. In epithelial cells of the colon,...