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The Cdc42 effectors ste20, Cla4, and Skm1 down-regulate the expression of genes involved in sterol uptake by a mitogen-activated protein kinase-independent pathway

Lin, Meng ; Unden, Heike ; Jacquier, Nicolas ; Schneiter, Roger ; Just, Ursula ; Höfken, Thomas

In: Molecular Biology of the Cell, 2009, vol. 20, no. 22, p. 4826-4837

In Saccharomyces cerevisiae, the Rho-type GTPase Cdc42 regulates polarized growth through its effectors, including the p21-activated kinases (PAKs) Ste20, Cla4, and Skm1. Previously, we demonstrated that Ste20 interacts with several proteins involved in sterol synthesis that are crucial for cell polarization. Under anaerobic conditions, sterols cannot be synthesized and need to be imported into...