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The period length of fibroblast circadian gene expression varies widely among human individuals

Brown, Steven A. ; Fleury-Olela, Fabienne ; Nagoshi, Emi ; Hauser, Conrad ; Juge, Cristiana ; Meier, Christophe A. ; Chicheportiche, Rachel ; Dayer, Jean-Michel ; Albrecht, Urs ; Schibler, Ueli

In: PLoS Biology, 2005, vol. 3(10), p. e338

Mammalian circadian behavior is governed by a central clock in the suprachiasmatic nucleus of the brain hypothalamus, and its intrinsic period length is believed to affect the phase of daily activities. Measurement of this period length, normally accomplished by prolonged subject observation, is difficult and costly in humans. Because a circadian clock similar to that of the suprachiasmatic...