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    2 risultati 1
    Université de Fribourg

    Β-Klotho deficiency protects against obesity through a crosstalk between liver, microbiota, and brown adipose tissue

    Somm, Emmanuel ; Henry, Hugues ; Bruce, Stephen J. ; Aeby, Sébastien ; Rosikiewicz, Marta ; Sykiotis, Gerasimos P. ; Asrih, Mohammed ; Jornayvaz, François R. ; Denechaud, Pierre Damien ; Albrecht, Urs ; Mohammadi, Moosa ; Dwyer, Andrew ; Jr., James S. Acierno ; Schoonjans, Kristina ; Fajas, Lluis ; Greub, Gilbert ; Pitteloud, Nelly

    In: JCI Insight, 2017, vol. 2, no. 8, p. -

    β-Klotho (encoded by Klb) is the obligate coreceptor mediating FGF21 and FGF15/19 signaling. Klb–/– mice are refractory to beneficial action of pharmacological FGF21 treatment including stimulation of glucose utilization and thermogenesis. Here, we investigated the energy homeostasis in Klb–/– mice on high-fat diet in order to better understand the consequences of abrogating both...

    Université de Fribourg

    Preserving of postnatal leptin signaling in obesity-resistant lou/c rats following a perinatal high-fat diet

    Poher, Anne-Laure ; Arsenijevic, Denis ; Asrih, Mohamed ; Dulloo, Abdul G. ; Jornayvaz, François R. ; Rohner-Jeanrenaud, Françoise ; Veyrat-Durebex, Christelle

    In: PLOS ONE, 2016, vol. 11, no. 9, p. e0162517

    Physiological processes at adulthood, such as energy metabolism and insulin sensitivity may originate before or weeks after birth. These underlie the concept of fetal and/or neonatal programming of adult diseases, which is particularly relevant in the case of obesity and type 2 diabetes. The aim of this study was to determine the impact of a perinatal high fat diet on energy metabolism and on...

    2 risultati 1