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Role of 3-mercaptopyruvate sulfurtransferase in the regulation of proliferation, migration, and bioenergetics in murine colon cancer cells

Augsburger, Fiona ; Randi, Elisa B. ; Jendly, Mathieu ; Ascencao, Kelly ; Nahzli Dilek ; Szabo, Csaba

In: Biomolecules, 2020, vol. 10, no. 3, p. 447

3-mercaptopyruvate sulfurtransferase (3-MST) has emerged as one of the significant sources of biologically active sulfur species in various mammalian cells. The current study was designed to investigate the functional role of 3- MST’s catalytic activity in the murine colon cancer cell line CT26. The novel pharmacological 3-MST inhibitor HMPSNE was used to assess cancer cell proliferation,...