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Tissue-specific transcription footprinting using RNA PoI DamID (RAPID) in Caenorhabditis elegans

Gómez-Saldivar, Georgina ; Osuna-Luque, Jaime ; Semple, Jennifer I. ; Glauser, Dominique A. ; Jarriault, Sophie ; Meister, Peter

In: Genetics, 2020, vol. 216, no. 4, p. 931–945

Differential gene expression across cell types underlies development and cell physiology in multicellular organisms. Caenorhabditis elegans is a powerful, extensively used model to address these biological questions. A remaining bottleneck relates to the difficulty to obtain comprehensive tissue-specific gene transcription data, since available methods are still challenging to execute and/or...