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Human anti–HIV-neutralizing antibodies frequently target a conserved epitope essential for viral fitness

Pietzsch, John ; Scheid, Johannes F. ; Mouquet, Hugo ; Klein, Florian ; Seaman, Michael S. ; Jankovic, Mila ; Corti, Davide ; Lanzavecchia, Antonio ; Nussenzweig, Michel C.

In: Journal of experimental medicine, 2010, vol. 207, no. 9, p. 1995-2002

The identification and characterization of conserved epitopes on the HIV-1 viral spike that are immunogenic in humans and targeted by neutralizing antibodies is an important step in vaccine design. Antibody cloning experiments revealed that 32% of all HIV-neutralizing antibodies expressed by the memory B cells in patients with high titers of broadly neutralizing antibodies recognize one or ...