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Granzyme B enters the mitochondria in a Sam50-, Tim22- and mtHsp70-dependent manner to induce apoptosis

Chiusolo, Valentina ; Jacquemin, Guillaume ; Bassoy, Esen Yonca ; Vinet, Laurent ; Liguori, Lavinia ; Walch, Michael ; Kozjak-Pavlovic, Vera ; Martinvalet, Denis

In: Cell Death & Differentiation, 2017, vol. 24, no. 4, p. 747–758

We have found that granzyme B (GB)-induced apoptosis also requires reactive oxygen species resulting from the alteration of mitochondrial complex I. How GB, which does not possess a mitochondrial targeting sequence, enter this organelle is unknown. We show that GB enters the mitochondria independently of the translocase of the outer mitochondrial membrane complex, but requires instead Sam50,...