Université de Fribourg

The cyclophilin A DIAGEOTROPICA gene affects auxin transport in both root and shoot to control lateral root formation

Ivanchenko, Maria G. ; Zhu, Jinsheng ; Wang, Bangjun ; Medvecká, Eva ; Du, Yunlong ; Azzarello, Elisa ; Mancuso, Stefano ; Megraw, Molly ; Filichkin, Sergei ; Dubrovsky, Joseph G. ; Friml, Jiří ; Geisler, Markus

In: Development, 2015, p. dev.113225

Cyclophilin A is a conserved peptidyl-prolyl cis-trans isomerase (PPIase) best known as the cellular receptor of the immunosuppressant cyclosporine A. Despite significant effort, evidence of developmental functions of cyclophilin A in non-plant systems has remained obscure. Mutations in a tomato (Solanum lycopersicum) cyclophilin A ortholog, DIAGEOTROPICA (DGT), have been shown to abolish the...