Université de Fribourg

Different Mi-2 Complexes for Various Developmental Functions in Caenorhabditis elegans

Passannante, Myriam ; Marti, Claude-Olivier ; Pfefferli, Catherine ; Moroni, Paolo S. ; Kaeser-Pebernard, Stéphanie ; Puoti, Alessandro ; Hunziker, Peter ; Wicky, Chantal ; Müller, Fritz

In: PLoS ONE, 2010, vol. 5, no. 10, p. e13681

Biochemical purifications from mammalian cells and Xenopus oocytes revealed that vertebrate Mi-2 proteins reside in multisubunit NuRD (Nucleosome Remodeling and Deacetylase) complexes. Since all NuRD subunits are highly conserved in the genomes of C. elegans and Drosophila, it was suggested that NuRD complexes also exist in invertebrates. Recently, a novel dMec complex, composed of dMi-2 and...