In: Pflügers Archiv - European Journal of Physiology, 2015, vol. 467, no. 12, p. 2529-2539
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In: Journal of the American Society of Nephrology, 2010, vol. 21, p. -
Lithium-induced nephrogenic diabetes insipidus (NDI) is accompanied by polyuria, downregulation of aquaporin 2 (AQP2), and cellular remodeling of the collecting duct (CD). The amiloride-sensitive epithelial sodium channel (ENaC) is a likely candidate for lithium entry. Here, we subjected transgenic mice lacking αENaC specifically in the CD (knockout [KO] mice) and littermate controls to chronic...
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In: PLoS ONE, 2015, vol. 10, no. 8, p. e0135224
The membrane-bound serine protease CAP2/Tmprss4 has been previously identified in vitro as a positive regulator of the epithelial sodium channel (ENaC). To study its in vivo implication in ENaC-mediated sodium absorption, we generated a knockout mouse model for CAP2/Tmprss4. Mice deficient in CAP2/Tmprss4 were viable, fertile, and did not show any obvious histological abnormalities. Unexpectedly,...
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In: Pflügers Archiv - European Journal of Physiology, 2009, vol. 458, no. 1, p. 211-222
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In: Human Molecular Genetics, 2002, vol. 11, no. 23, p. 2829-2836
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