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    2 results 1
    Université de Fribourg

    High-risk KPC-producing Klebsiella pneumoniae lack type I R-M systems

    Zhou, Ying ; Tian, Dongxing ; Tang, Yu ; Yu, Lianhua ; Huang, Yunkun ; Li, Gang ; Li, Meng ; Wang, Yong ; Yang, Zehua ; Poirel, Laurent ; Jiang, Xiaofei

    In: International Journal of Antimicrobial Agents, 2020, vol. 56, no. 2, p. 106050

    Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae (KPC-KP) have disseminated worldwide and are a major threat to public health. The multidrug- resistant (MDR)-phenotype of KPC-KP are commonly associated with the presence of high molecular weight blaKPC plasmids. Restriction-modification (R-M) systems provide bacteria with innate defense against plasmids or other infectious gene...

    Université de Fribourg

    The type I-E CRISPR-Cas system influences the acquisition of bla KPC-IncF plasmid in Klebsiella pneumonia

    Zhou, Ying ; Tang, Yu ; Fu, Pan ; Tian, Dongxing ; Yu, Lianhua ; Huang, Yunkun ; Li, Gang ; Li, Meng ; Wang, Yong ; Yang, Zehua ; Xu, Xiaogang ; Yin, Zhe ; Zhou, Dongsheng ; Poirel, Laurent ; Jiang, Xiaofei

    In: Emerging Microbes & Infections, 2020, vol. 9, no. 1, p. 1011–1022

    Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae (KPC-KP) have disseminated worldwide and emerged as major threats to public health. Of epidemiological significance, the international pandemic of KPC-KP is primarily associated with CG258 isolates and bla KPC-IncF plasmids. CRISPR-Cas system is an adaptive immune system that can hinder gene expansion driven by horizontal gene ...

    2 results 1