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Alpha‐synuclein dopaminylation presented in plasma of both healthy subjects and parkinson’s disease patients

Zhao, Huiyuan ; Huang, Shuai ; Palanisamy, Sivakumar ; Wang, Cui ; Rainer, Gregor ; Zhang, Xiaozhe

In: PROTEOMICS – Clinical Applications, 2020, vol. 14, no. 5, p. 1900117

Alpha‐synuclein (α‐syn) dopaminylation can lead to the death of dopaminergic neurons in the brain and is a risk factor of Parkinson's disease (PD). This study aims to examine whether such a posttranslational modification (PTM) is presented in human blood plasma. Experimental Design: In vitro reaction simulation between α‐syn and dopamine (DA) is conducted to study the biochemical...