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Oriented basement membrane fibrils provide a memory for F-actin planar polarization via the Dystrophin-Dystroglycan complex during tissue elongation

Cerqueira Campos, Fabiana ; Dennis, Cynthia ; Alégot, Hervé ; Fritsch, Cornelia ; Isabella, Adam ; Pouchin, Pierre ; Bardot, Olivier ; Horne-Badovinac, Sally ; Mirouse, Vincent

In: Development, 2020, vol. 147, no. 7, p. dev186957

How extracellular matrix contributes to tissue morphogenesis is still an open question. In the Drosophila ovarian follicle, it has been proposed that after Fat2-dependent planar polarization of the follicle cell basal domain, oriented basement membrane (BM) fibrils and F-actin stress fibers constrain follicle growth, promoting its axial elongation. However, the relationship between BM fibrils...