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NONO couples the circadian clock to the cell cycle

Kowalska, Elzbieta ; Ripperger, Jürgen A. ; Hoegger, Dominik C. ; Bruegger, Pascal ; Buch, Thorsten ; Birchler, Thomas ; Mueller, Anke ; Albrecht, Urs ; Contaldo, Claudio ; Brown, Steven A.

In: Proceedings of the National Academy of Sciences - PNAS, 2013, vol. 110, no. 5, p. 1592-1599

Mammalian circadian clocks restrict cell proliferation to defined time windows, but the mechanism and consequences of this interrelationship are not fully understood. Previously we identified the multifunctional nuclear protein NONO as a partner of circadian PERIOD (PER) proteins. Here we show that it also conveys circadian gating to the cell cycle, a connection surprisingly important for...