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Development of resiquimod-loaded modified PLA-based nanoparticles for cancer immunotherapy: A kinetic study

Thauvin, Cédric ; Widmer, Jérôme ; Mottas, Inès ; Hocevar, Sandra ; Allémann, Eric ; Bourquin, Carole ; Delie, Florence

In: European Journal of Pharmaceutics and Biopharmaceutics, 2019, vol. 139, p. 253–261

Resiquimod (R848), a member of the imidazoquinoline family, is a Toll-like receptor 7/8 agonist with high potency for cancer immunotherapy. However, tolerance induction and adverse effects limit its development as a drug. Encapsulation in a polymer matrix can circumvent these limitations, as shown in our formerly published approach where R848 was loaded into polylactic acid (PLA)-based...