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Theranostic body fluid cleansing: rationally designed magnetic particles enable capturing and detection of bacterial pathogens

Lattuada, Marco ; Ren, Q. ; Zuber, F. ; Galli, M. ; Bohmer, N. ; Matter, M. T. ; Wichser, A. ; Bertazzo, S. ; Pier, G. B. ; Herrmann, I. K.

In: Journal of Materials Chemistry B, 2016, vol. 4, no. 44, p. 7080–7086

We report on theoretical and experimental considerations on bacteria capturing and enrichment via magnetic separation enabling integrated diagnosis and treatment of blood stream infections. We show optimization of carrier-pathogen interactions based on a mathematical model followed by an experimental proof-of-concept study along with investigations on the process safety.