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EEF1A1 deacetylation enables transcriptional activation of remyelination

Duman, Mert ; Vaquié, Adrien ; Nocera, Gianluigi ; Heller, Manfred ; Stumpe, Michael ; Sankar, Devanarayanan Siva ; Dengjel, Jörn ; Meijer, Dies ; Yamaguchi, Teppei ; Matthias, Patrick ; Zeis, Thomas ; Schaeren-Wiemers, Nicole ; Hayoz, Antoinette ; Ruff, Sophie ; Jacob, Claire

In: Nature Communications, 2020, vol. 11, no. 1, p. 3420

Remyelination of the peripheral and central nervous systems (PNS and CNS, respectively) is a prerequisite for functional recovery after lesion. However, this process is not always optimal and becomes inefficient in the course of multiple sclerosis. Here we show that, when acetylated, eukaryotic elongation factor 1A1 (eEF1A1) negatively regulates PNS and CNS remyelination. Acetylated eEF1A1...

FUS/TLS contributes to replication-dependent histone gene expression by interaction with U7 snRNPs and histone-specific transcription factors

Raczynska, Katarzyna Dorota ; Ruepp, Marc-David ; Brzek, Aleksandra ; Reber, Stefan ; Romeo, Valentina ; Rindlisbacher, Barbara ; Heller, Manfred ; Szweykowska-Kulinska, Zofia ; Jarmolowski, Artur ; Schümperli, Daniel

In: Nucleic Acids Research, 2015, vol. 43, no. 20, p. 9711-9728

Delaying histone deacetylase response to injury accelerates conversion into repair Schwann cells and nerve regeneration

Brügger, Valérie ; Duman, Mert ; Bochud, Maëlle ; Münger, Emmanuelle ; Heller, Manfred ; Ruff, Sophie ; Jacob, Claire

In: Nature Communications, 2017, vol. 8, p. 14272

The peripheral nervous system (PNS) regenerates after injury. However, regeneration is often compromised in the case of large lesions, and the speed of axon reconnection to their target is critical for successful functional recovery. After injury, mature Schwann cells (SCs) convert into repair cells that foster axonal regrowth, and redifferentiate to rebuild myelin. These processes require...