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Mouse model of type II Bartter's syndrome. II. Altered expression of renal sodium- and water-transporting proteins

Wagner, Carsten A. ; Loffing-Cueni, Dominique ; Yan, Qingshang ; Schulz, Nicole ; Fakitsas, Panagiotis ; Carrel, Monique ; Wang, Tong ; Verrey, François ; Geibel, John P. ; Giebisch, Gerhard ; Hebert, Steven C. ; Loffing, Johannes

In: American Journal of Physiology: Renal Physiology, 2008, vol. 294, no. 6, p. F1373-F1380

ROMK-deficient (Romk–/–) mice exhibit polyuria, natriuresis, and kaliuresis similar to individuals with type II Bartter's form of hyperprostaglandin E syndrome (HPS; antenatal Bartter's syndrome). In the present study, we utilized both metabolic and clearance studies to define the contributions of specific distal nephron segments to the renal salt wasting in these mice. The...