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Measurement of ultra-trace level of intact oxytocin in plasma using SALLE combined with nano-LC–MS

Liu, Dan ; Han, Xiaoli ; Liu, Xinxin ; Cheng, Mengchun ; He, Meixi ; Rainer, Gregor ; Gao, Huiyuan ; Zhang, Xiaozhe

In: Journal of Pharmaceutical and Biomedical Analysis, 2019, vol. 173, p. 62–67

Measurement of peptides such as oxytocin in plasma is a critical challenge in clinical research because of their extreme low concentrations as well as the tremendous interferencing substances co-presented in plasma. In this study, we developed an efficient salt-out assisted liquid-liquid extraction (SALLE) to treat plasma, and then analyzed the samples using nano-LC–MS to quantify intact...