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Intestinal microbiota drives cholestasis-induced specific hepatic gene expression patterns

Juanola, Oriol ; Hassan, Mohsin ; Kumar, Pavitra ; Yilmaz, Bahtiyar ; Keller, Irene ; Simillion, Cédric ; Engelmann, Cornelius ; Tacke, Frank ; Dufour, Jean-François ; De Gottardi, Andrea ; Moghadamrad, Sheida

In: Gut microbes, 2021, vol. 13, no. 1, p. 20

Intestinal microbiota regulates multiple host metabolic and immunological processes. Consequently, any difference in its qualitative and quantitative composition is susceptible to exert significant effects, in particular along the gut-liver axis. Indeed, recent findings suggest that such changes modulate the severity and the evolution of a wide spectrum of hepatobiliary disorders. However, the...