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Structure and conserved function of iso-branched sphingoid bases from the nematode Caenorhabditis elegans

Hannich, J. Thomas ; Mellal, Denia ; Feng, Suihan ; Zumbuehl, Andreas ; Riezman, Howard

In: Chemical Science, 2017, vol. 8, no. 5, p. 3676–3686

Sphingolipids are bio-active metabolites that show structural diversity among eukaryotes. They are essential for growth of all eukaryotic cells but when produced in an uncontrolled manner can lead to cell death and pathologies including auto-immune reactions, cancer, diabetes and neurodegeneration. Caenorhabditis elegans is an important genetic model organism both to find new drug-targets...