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In vivo nuclear translocation of mineralocorticoid and glucocorticoid receptors in rat kidney: differential effect of corticosteroids along the distal tubule

Ackermann, Daniel ; Gresko, Nikolay ; Carrel, Monique ; Loffing-Cueni, Dominique ; Habermehl, Daniel ; Gomez-Sanchez, Celso ; Rossier, Bernard C. ; Loffing, Johannes

In: American Journal of Physiology - Renal Physiology, 2011, vol. 299, no. 6, p. F1473-F1485

Aldosterone and corticosterone bind to mineralocorticoid (MR) and glucocorticoid receptors (GR), which, upon ligand binding, are thought to translocate to the cell nucleus to act as transcription factors. Mineralocorticoid selectivity is achieved by the 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2) that inactivates 11β-hydroxy glucocorticoids. High expression levels of 11β-HSD2...