Université de Fribourg

Considering the degradation effects of amino-functional plasma polymer coatings for biomedical application

Hegemann, Dirk ; Hanselmann, Barbara ; Guimond, Sébastien ; Fortunato, Giuseppino ; Giraud, Marie-Noëlle ; Guex, Anne Géraldine

In: Surface and Coatings Technology, 2014, vol. 255, p. 90–95

Materials for biomedical applications typically involve surface engineering. Scaffolds used for tissue engineering, for example, require a surface functionalization in order to support cell growth. The deposition of functional plasma polymer coatings seems to be an attractive approach to modify substrates for biomedical applications.Possible degradation of highly functional plasma polymers and...

Université de Fribourg

Anisotropically oriented electrospun matrices with an imprinted periodic micropattern: a new scaffold for engineered muscle constructs

Guex, Anne Géraldine ; Birrer, Dominique Lisa ; Fortunato, Giuseppino ; Tevaearai, Hendrik Tinorua ; Giraud, Marie-Noëlle

In: Biomedical Materials, 2013, vol. 8, no. 2, p. 021001

Engineered muscle constructs provide a promising perspective on the regeneration or substitution of irreversibly damaged skeletal muscle. However, the highly ordered structure of native muscle tissue necessitates special consideration during scaffold development. Multiple approaches to the design of anisotropically structured substrates with grooved micropatterns or parallel-aligned fibres have...

Université de Fribourg

Cell therapies for heart function recovery: focus on myocardial tissue engineering and nanotechnologies

Giraud, Marie Noëlle ; Guex, Anne Géraldine ; Tevaearai, Hendrik T.

In: Cardiology Research and Practice, 2012, p. -

Cell therapies have gained increasing interest and developed in several approaches related to the treatment of damaged myocardium. The results of multiple clinical trials have already been reported, almost exclusively involving the direct injection of stem cells. It has, however, been postulated that the efficiency of injected cells could possibly be hindered by the mechanical trauma due to the...