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Mitochondrial tRNALeu(UUR) mutation m.3302A > G presenting as childhood-onset severe myopathy: threshold determination through segregation study

Ballhausen, Diana ; Guerry, Frédéric ; Hahn, Dagmar ; Schaller, André ; Nuoffer, Jean-Marc ; Bonafé, Luisa ; Jeannet, Pierre-Yves ; Jacquemont, Sebastien

In: Journal of Inherited Metabolic Disease, 2010, vol. 33, p. 219-226

The Mi-2 nucleosome-remodeling protein LET-418 is targeted via LIN-1/ETS to the promoter of lin-39/Hox during vulval development in C. elegans

Guerry, Frédéric ; Marti, Claude-Olivier ; Zhang, Yue ; Moroni, Paolo S. ; Jaquiéry, Emilie ; Müller, Fritz

In: Developmental Biology, 2007, vol. 206, no. 2, p. 469-479

The fate of the vulval cells in Caenorhabditis elegans is specified, at least in part, through a highly conserved RTK/Ras mediated signaling cascade that negatively regulates the activity of the ETS-like transcription factor LIN-1. The Hox gene lin-39 functions downstream of both, the LIN-3/RTK/Ras pathway and LIN-1 and plays a pivotal role in controlling vulva cell competence and...

Transcriptional control of Notch signaling by a HOX and a PBX/EXD protein during vulval development in C. elegans

Takács-Vellai, Krisztina ; Vellai, Tibor ; Chen, Estella B. ; Zhang, Yue ; Guerry, Frédéric ; Stern, Michael J. ; Müller, Fritz

In: Developmental Biology, 2007, vol. 302, no. 2, p. 661–669

The Notch signaling pathway controls growth, differentiation and patterning in divergent animal phyla; in humans, defective Notch signaling has been implicated in cancer, stroke and neurodegenerative disorders. Despite its developmental and medical significance, little is known about the factors that render cells to become competent for Notch signaling. Here we show that during vulval development...