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Backbone and side chain NMR assignments of the H-NOX domain from Nostoc sp. in complex with BAY58-2667 (cinaciguat)

Makrynitsa, Garyfallia I. ; Argyriou, Aikaterini I. ; Dalkas, Georgios ; Georgopoulou, Dimitra A. ; Bantzi, Marina ; Giannis, Athanassios ; Papapetropoulos, Andreas ; Spyroulias, Georgios A.

In: Biomolecular NMR Assignments, 2020, p. -

Soluble guanylate cyclase (sGC) enzyme is activated by the gaseous signaling agent nitric oxide (NO) and triggers the conversion of GTP (guanosine 5′-triphosphate) to cGMP (cyclic guanylyl monophosphate). It contains the heme binding H-NOX (heme- nitric oxide/oxygen binding) domain which serves as the sensor of NO and it is highly conserved across eukaryotes and bacteria as well. Many...