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Università della Svizzera italiana

International prognostic score for asymptomatic early-stage chronic lymphocytic leukemia

Condoluci, Adalgisa ; Terzi di Bergamo, Lodovico ; Langerbeins, Petra ; Hoechstetter, Manuela A. ; Herling, Carmen D. ; De Paoli, Lorenzo ; Delgado, Julio ; Rabe, Kari G. ; Gentile, Massimo ; Doubek, Michael ; Mauro, Francesca R. ; Chiodin, Giorgia ; Mattsson, Mattias ; Bahlo, Jasmin ; Cutrona, Giovanna ; Kotaskova, Jana ; Deambrogi, Clara ; Smedby, Karin E. ; Spina, Valeria ; Bruscaggin, Alessio ; Wu, Wei ; Moia, Riccardo ; Bianchi, Elena ; Gerber, Bernhard ; Zucca, Emanuele ; Gillessen, Silke ; Ghielmini, Michele ; Cavalli, Franco ; Stussi, Georg ; Hess, Mark A. ; Baumann, Tycho S. ; Neri, Antonino ; Ferrarini, Manlio ; Rosenquist, Richard ; Forconi, Francesco ; Foà, Robin ; Pospisilova, Sarka ; Morabito, Fortunato ; Stilgenbauer, Stephan ; Döhner, Hartmut ; Parikh, Sameer A. ; Wierda, William G. ; Montserrat, Emili ; Gaidano, Gianluca ; Hallek, Michael ; Rossi, Davide

In: Blood, 2020, vol. 135, no. 21, p. 1859–1869

Most patients with chronic lymphocytic leukemia (CLL) are diagnosed with early-stage disease and managed with active surveillance. The individual course of patients with early-stage CLL is heterogeneous, and their probability of needing treatment is hardly anticipated at diagnosis. We aimed at developing an international prognostic score to predict time to first treatment (TTFT) in patients...

Università della Svizzera italiana

CD49d promotes disease progression in chronic lymphocytic leukemia : new insights from CD49d bimodal expression

Tissino, Erika ; Pozzo, Federico ; Benedetti, Dania ; Caldana, Chiara ; Bittolo, Tamara ; Rossi, Francesca Maria ; Bomben, Riccardo ; Nanni, Paola ; Chivilò, Hillarj ; Cattarossi, Ilaria ; Zaina, Eva ; Norris, Kevin ; Polesel, Jerry ; Gentile, Massimo ; Tripepi, Giovanni ; Moia, Riccardo ; Santinelli, Enrico ; Innocenti, Idanna ; Olivieri, Jacopo ; D’Arena, Giovanni ; Laurenti, Luca ; Zaja, Francesco ; Pozzato, Gabriele ; Chiarenza, Annalisa ; Di Raimondo, Francesco ; Rossi, Davide ; Pepper, Chris ; Hartmann, Tanja Nicole ; Gaidano, Gianluca ; Del Poeta, Giovanni ; Gattei, Valter ; Zucchetto, Antonella

In: Blood, 2020, vol. 135, no. 15, p. 1244–1254

CD49d is a remarkable prognostic biomarker of chronic lymphocytic leukemia (CLL). The cutoff value for the extensively validated 30% of positive CLL cells is able to separate CLL patients into 2 subgroups with different prognoses, but it does not consider the pattern of CD49d expression. In the present study, we analyzed a cohort of 1630 CLL samples and identified the presence of ∼20% of CLL...

2 résultats 1