Université de Fribourg

Expression of granulisyn, perforin and granzymes in human milk over lactation and in the case of maternal infection

Twigger, Alecia-Jane ; Küffer, Gwendoline K. ; Geddes, Donna T. ; Filgueria, Luis

In: Nutrients, 2018, vol. 10, no. 9, p. 1230

Human milk has been previously found to contain various types of leukocytes however specific characteristics of these cells, such as whether they contain cytolytic antimicrobial proteins that may induce pathogen directed cell death, are unknown. This project aims to examine the presence and localization of immune proteins such as perforin, granulysin and granzymes in human milk cells at the...

Université de Fribourg

Breastmilk cell and fat contents respond similarly to removal of breastmilk by the infant

Hassiotou, Foteini ; Hepworth, Anna R. ; Williams, Tracey M. ; Twigger, Alecia-Jane ; Perrella, Sharon ; Lai, Ching Tat ; Filgueira, Luis ; Geddes, Donna T. ; Hartmann, Peter E.

In: PLoS ONE, 2013, vol. 8, no. 11, p. e78232

Large inter- and intra-individual variations exist in breastmilk composition, yet factors associated with these variations in the short-term are not well understood. In this study, the effects of breastfeeding on breastmilk cellular and biochemical content were examined. Serial breastmilk samples (~5 mL) were collected from both breasts of breastfeeding women before and immediately after the...