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Multilevel regulation of the glass locus during Drosophila eye development

Fritsch, Cornelia ; Bernardo-Garcia, F. Javier ; Humberg, Tim-Henning ; Mishra, Abhishek Kumar ; Miellet, Sara ; Almeida, Silvia ; Frochaux, Michael V. ; Deplancke, Bart ; Huber, Armin ; Sprecher, Simon G.

In: PLOS Genetics, 2019, vol. 15, no. 7, p. e1008269

Development of eye tissue is initiated by a conserved set of transcription factors termed retinal determination network (RDN). In the fruit fly Drosophila melanogaster, the zinc-finger transcription factor Glass acts directly downstream of the RDN to control identity of photoreceptor as well as non-photoreceptor cells. Tight control of spatial and temporal gene expression is a critical...