In: Brain, 2016, vol. 139, no. 6, p. 1855-1861
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Thèse de doctorat : Université de Fribourg, 2008 ; Nr. 1592.
After injury to the adult central nervous system (CNS), permanent deficits remain to a large part due to limited cell renewal, axonal regeneration and reestablishment of functional connectivity. Evidence indicate that the lack of axonal regeneration is partly due to the myelin-associated inhibitory factor Nogo-A. A therapeutical strategy to overcome this inhibition is to prevent the neurite...
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In: BMC Neuroscience, 2009, vol. 10, p. 155
Background Polymicrogyria is a malformation of the cerebral cortex often resulting in epilepsy or mental retardation. It remains unclear whether this pathology affects the structure and function of the corticospinal (CS) system. The anatomy and histology of the brain of one macaque monkey exhibiting a spontaneous polymicrogyria (PMG monkey) were examined and compared to the brain of normal...
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In: European Journal of Neuroscience, 2009, vol. 29, no. 5, p. 983 - 996
In rodents and nonhuman primates subjected to spinal cord lesion, neutralizing the neurite growth inhibitor Nogo-A has been shown to promote regenerative axonal sprouting and functional recovery. The goal of the present report was to re-examine the data on the recovery of the primate manual dexterity using refined behavioral analyses and further statistical assessments, representing secondary...
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In: Brain Research, 2008, vol. 1217, p. 96-109
The present study describes in primates the effects of a spinal cord injury on the number and size of the neurons in the magnocellular part of the red nucleus (RNm), the origin of the rubrospinal tract, and evaluates whether a neutralization of Nogo-A reduces the lesioned-induced degenerative processes observed in RNm. Two groups of monkeys were subjected to unilateral section of the spinal cord...
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In: Somatosensory and Motor Research, 2008, vol. 25, no. 1, p. 77 - 92
The present study aimed at investigating the time span it takes to remove a static mechanical allodynia (SMA) in humans suffering from chronic peripheral neuropathic pain. Forty-three subjects were included in the study and, during somatosensory rehabilitation, their SMA territory was precisely mapped. They then underwent distant vibrotactile counter stimulation (DVCS) treatment. It was observed...
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In: BMC Neuroscience, 2008, vol. 9, no. 1, p. 5
Background: After unilateral cervical cord lesion at the C7/C8 border interrupting the dorsolateral funiculus in adult monkeys, neutralization of Nogo-A using a specific monoclonal antibody promoted sprouting of corticospinal (CS) axons rostral and caudal to the lesion and, in parallel, improved functional recovery. In monkeys lesioned but not treated with the anti-Nogo-A antibody, the CS neurons...
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In: The Journal of Comparative Neurology, 2007, vol. 502, no. 4, p. 644 - 659
After injury, regrowth of axons in mammalian adult central nervous system is highly limited. However, in monkeys subjected to unilateral cervical lesion (C7-C8 level), neutralization of an important neurite outgrowth inhibitor, Nogo-A, stimulated axonal sprouting caudal to the lesion, accompanied by enhanced functional recovery of manual dexterity, compared with lesioned monkeys treated with a...
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In: Nature Medicine
In rodents, after spinal lesion, neutralizing the neurite growth inhibitor Nogo-A promotes axonal sprouting and functional recovery. To evaluate this treatment in primates, 12 monkeys were subjected to cervical lesion. Recovery of manual dexterity and sprouting of corticospinal axons were enhanced in monkeys treated with Nogo-A– specific antibody as compared to monkeys treated with control...
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