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Computational modeling of shear forces and experimental validation of endothelial cell responses in an orbital well shaker system

Filipovic, Nenad ; Ghimire, Kedar ; Saveljic, Igor ; Milosevic, Zarko ; Rüegg, Curzio

In: Computer Methods in Biomechanics and Biomedical Engineering, 2016, vol. 19, no. 6, p. 581–590

Vascular endothelial cells are continuously exposed to hemodynamic shear stress. Intensity and type of shear stress are highly relevant to vascular physiology and pathology. Here, we modeled shear stress distribution in a tissue culture well (R = 17.5 mm, fill volume 2 ml) under orbital translation using computational fluid dynamics with the finite element method. Free surface distribution,...