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    2 results 1
    Université de Fribourg

    Posttranscriptional regulation controls calretinin expression in malignant pleural mesothelioma

    Kresoja-Rakic, Jelena ; Sulemani, Merve ; Kirschner, Michaela B. ; Ronner, Manuel ; Reid, Glen ; Kao, Steven ; Schwaller, Beat ; Weder, Walter ; Stahel, Rolf A.

    In: Frontiers in Genetics, 2017, vol. 8, p. -

    Calretinin (CALB2) is a diagnostic and prognostic marker in malignant pleural mesothelioma (MPM). We previously reported that calretinin expression is regulated at the mRNA level. The presence of a medium-sized (573 nucleotide) 3′ untranslated region (3′UTR) predicted to contain binding sites for miR-30a/b/c/d/e and miR-9 as well as an adenine/uridine-rich element (ARE) in all three...

    Université de Fribourg

    Identification of cis- and trans-acting elements regulating calretinin expression in mesothelioma cells

    Kresoja-Rakic, Jelena ; Kapaklikaya, Esra ; Ziltener, Gabriela ; Dalcher, Damian ; Santoro, Raffaella ; Christensen, Brock C. ; Johnson, Kevin C. ; Schwaller, Beat ; Weder, Walter ; Stahel, Rolf A. ; Felley-Bosco, Emanuela

    In: Oncotarget, 2016, vol. 7, no. 16, p. 21272–21286

    Calretinin (CALB2) is a diagnostic marker for epithelioid mesothelioma. It is also a prognostic marker since patients with tumors expressing high calretinin levels have better overall survival. Silencing of calretinin decreases viability of epithelioid mesothelioma cells. Our aim was to elucidate mechanisms regulating calretinin expression in mesothelioma. Analysis of calretinin transcript...

    2 results 1