In: Addiction Biology, 2017, vol. 22, no. 2, p. 411–422
The drive to eat is regulated by two compensatory brain pathways termed as homeostatic and hedonic. Hypothalamic orexinergic (ORX) neurons regulate metabolism, feeding and reward, thus controlling physiological and hedonic appetite. Circadian regulation of feeding, metabolism and rhythmic activity of ORX cells are driven by the brain suprachiasmatic clock. How the circadian clock impacts on...
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In: Journal of Neuroendocrinology, 2010, p. -
Many daily cycles are imposed on us by our environment, such as alternating days and nights, temperature fluctuations or rhythms in food availability. When food is accessible every day at the same time, animals will adapt their physiology and behaviour to match the daily meal. They will anticipate the access to food by waking up and being active in the hours prior to feeding, foraging for food....
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In: Journal of Physiology-Paris, 2006, vol. 100, no. 5-6, p. 252-260
Circadian clocks are autonomous time-keeping mechanisms that allow living organisms to predict and adapt to environmental rhythms of light, temperature and food availability. At the molecular level, circadian clocks use clock and clock-controlled genes to generate rhythmicity and distribute temporal signals. In mammals, synchronization of the master circadian clock located in the suprachiasmatic...
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In: Molecular and Cellular Neuroscience, 2008, vol. 37, no. 2, p. 209-221
Clock proteins like PER1 and PER2 are expressed in the brain, but little is known about their functionality outside the main suprachiasmatic clock. Here we show that PER1 and PER2 were neither uniformly present nor identically phased in forebrain structures of mice fed ad libitum. Altered expression of the clock gene Cry1 was observed in respective Per1 or Per2 mutants. In response to hypocaloric...
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In: Current Biology, 2006, vol. 16, no. 20, p. 2016-2022
Predicting time of food availability is key for survival in most animals. Under restricted feeding conditions, this prediction is manifested in anticipatory bouts of locomotor activity and body temperature. This process seems to be driven by a food-entrainable oscillator independent of the main, light-entrainable clock located in the suprachiasmatic nucleus (SCN) of the hypothalamus 1 and 2....
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