Perfeziona i miei risultati

Biological and clinical implications of BIRC3 mutations in chronic lymphocytic leukemia

Diop, Fary ; Moia, Riccardo ; Favini, Chiara ; Spaccarotella, Elisa ; De Paoli, Lorenzo ; Bruscaggin, Alessio ; Spina, Valeria ; Terzi-di-Bergamo, Lodovico ; Arruga, Francesca ; Tarantelli, Chiara ; Deambrogi, Clara ; Rasi, Silvia ; Adhinaveni, Ramesh ; Patriarca, Andrea ; Favini, Simone ; Sagiraju, Sruthi ; Jabangwe, Clive ; Kodipad, Ahad A. ; Peroni, Denise ; Mauro, Francesca R. ; Del Giudice, Ilaria ; Forconi, Francesco ; Cortelezzi, Agostino ; Zaja, Francesco ; Bomben, Riccardo ; Rossi, Francesca Maria ; Visco, Carlo ; Chiarenza, Annalisa ; Rigolin, Gian Matteo ; Marasca, Roberto ; Coscia, Marta ; Perbellini, Omar ; Tedeschi, Alessandra ; Laurenti, Luca ; Motta, Marina ; Donaldson, David ; Weir, Phil ; Mills, Ken ; Thornton, Patrick ; Lawless, Sarah ; Bertoni, Francesco ; Del Poeta, Giovanni ; Cuneo, Antonio ; Follenzi, Antonia ; Gattei, Valter ; Boldorini, Renzo Luciano ; Catherwood, Mark ; Deaglio, Silvia ; Foà, Robin ; Gaidano, Gianluca ; Rossi, Davide

In: Haematologica, 2020, vol. 105, no. 2, p. 448-456

BIRC3 is a recurrently mutated gene in chronic lymphocytic leukemia (CLL) but the functional implications of BIRC3 mutations are largely unexplored. Furthermore, little is known about the prognostic impact of BIRC3 mutations in CLL cohorts homogeneously treated with first-line fludarabine, cyclophosphamide, and rituximab (FCR). By immunoblotting analysis, we showed that the non-canonical...