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Microglia at center stage: a comprehensive review about the versatile and unique residential macrophages of the central nervous system

Lannes, Nils ; Eppler, Elisabeth ; Etemad, Samar ; Yotovski, Peter ; Filgueira, Luis

In: Oncotarget, 2017, vol. 8, no. 69, p. 114393–114413

Microglia cells are the unique residential macrophages of the central nervous system (CNS). They have a special origin, as they derive from the embryonic yolk sac and enter the developing CNS at a very early stage. They play an important role during CNS development and adult homeostasis. They have a major contribution to adult neurogenesis and neuroinflammation. Thus, they participate in the...