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Altered Sleep Homeostasis in Rev-erbα Knockout Mice

Mang, Géraldine M. ; La Spada, Francesco ; Emmenegger, Yann ; Chappuis, Sylvie ; Ripperger, Jürgen A. ; Albrecht, Urs ; Franken, Paul

In: Sleep, 2016, vol. 39, no. 3, p. 589-601

Electroencephalogram paroxysmal theta characterizes cataplexy in mice and children

Vassalli, Anne ; Dellepiane, Jose M. ; Emmenegger, Yann ; Jimenez, Sonia ; Vandi, Stefano ; Plazzi, Giuseppe ; Franken, Paul ; Tafti, Mehdi

In: Brain, 2013, vol. 136, no. 5, p. 1592-1608

Altered sleep homeostasis in rev-erbα knockout mice

Mang, Géraldine M. ; La Spada, Francesco ; Emmenegger, Yann ; Chappuis, Sylvie ; Ripperger, Jürgen A. ; Albrecht, Urs ; Franken, Paul

In: SLEEP, 2016, vol. 39, no. 3, p. 589–601

Study Objectives: The nuclear receptor REV-ERBα is a potent, constitutive transcriptional repressor critical for the regulation of key circadian and metabolic genes. Recently, REV-ERBα's involvement in learning, neurogenesis, mood, and dopamine turnover was demonstrated suggesting a specific role in central nervous system functioning. We have previously shown that the brain expression of...

cGMP-dependent protein kinase type I is implicated in the regulation of the timing and quality of sleep and wakefulness

Langmesser, Sonja ; Franken, Paul ; Feil, Susanne ; Emmenegger, Yann ; Albrecht, Urs ; Feil, Robert

In: PLoS ONE, 2009, vol. 4, no. 1, p. e4238

Many effects of nitric oxide (NO) are mediated by the activation of guanylyl cyclases and subsequent production of the second messenger cyclic guanosine-3′,5′-monophosphate (cGMP). cGMP activates cGMP-dependent protein kinases (PRKGs), which can therefore be considered downstream effectors of NO signaling. Since NO is thought to be involved in the regulation of both sleep and circadian...