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    Université de Fribourg

    Seipin and Nem1 establish discrete ER subdomains to initiate yeast lipid droplet biogenesis

    Choudhary, Vineet ; El Atab, Ola ; Mizzon, Giulia ; Prinz, William A. ; Schneiter, Roger

    In: Journal of Cell Biology, 2020, vol. 219, no. 7, p. -

    Lipid droplets (LDs) are fat storage organelles that originate from the endoplasmic reticulum (ER). Relatively little is known about how sites of LD formation are selected and which proteins/lipids are necessary for the process. Here, we show that LDs induced by the yeast triacylglycerol (TAG)-synthases Lro1 and Dga1 are formed at discrete ER subdomains defined by seipin (Fld1), and a...

    Université de Fribourg

    Plant pathogenesis-related proteins of the cacao fungal pathogen Moniliophthora perniciosa differ in their lipid-binding specificities

    Darwiche, Rabih ; El Atab, Ola ; Baroni, Renata Moro ; Teixeira, Paulo J. P. L. ; Mondego, Jorge M. C. ; Pereira, Gonçalo A. G. ; Schneiter, Roger

    In: Journal of Biological Chemistry, 2017, p. jbc.M117.811398

    Moniliophthora perniciosa is the causative agent of witches' broom disease, which devastates cacao cultures in South America. This pathogenic fungus infects meristematic tissues and derives nutrients from the plant apoplast during an unusually long-lasting biotrophic stage. In order to survive, the fungus produces proteins to suppress the plant immune response. Proteins of the Pathogenesis...

    2 résultats 1