In: Metallomics, 2012, vol. 4, no. 3, p. 253-259
The HEW lysozyme (Lys) and the fac-[Re(CO)3(H2O)3]+ complex (1) are used as a simple model system for the description of a new approach to the labelling polypeptides with fluorescent tags. The strategy takes advantage of the reaction of an acridine orange-based fluorophore (AO) with the non-native metal fragment 1 hybridized on the enzyme. A synthetic methodology for the quantitative...
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In: Inorganic Chemistry, 2009, vol. 48, no. 11, p. 4963-4970
The chemistry of [(tacn)-N-CO-Re(III)(CO)(2)Br]X (X = Cl or Br), obtained in good yield from the reaction of fac-[(tacn)Re(I)(CO)(3)]Br (1, tacn = 1,4,7- triazacyclononane) with X(2) in water, is described. The [(tacn)-N-CO-Re(III)(CO) (2)Br]X complex (2 with X = Br(-); 2a with X = BrCl(2)(-)), which we have previously communicated, is characterized by an unusual three-membered ring acyl amide...
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In: Inorganic Chemistry, 2010, vol. 49, no. 22, p. 10370-10377
The electronic description of octahedral (fac-[M(CO)(3)L(3)](n), with M = Re, Ru, and Mn, and [Cr(CO)(5)L](n)), square-planar (cis-[Pt(CO)(2)L(2)](n)), and tetrahedral ([Ni(CO)(3)L](n)) carbonyl complexes (where L = monodentate ligand) was obtained via density functional theory and natural population analyses in order to understand what effects are probed in these species by vibrational...
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In: Inorganic Chemistry, 2009, vol. 48, no. 22, p. 10845-10855
A ligand parameter, IR(P)(L), is introduced in order to evaluate the effect that different monodentate and bidentate ligands have on the symmetric C[triple bond]O stretching frequency of octahedral d(6) fac-[Re(CO)(3)L(3)] complexes (L = mono- or bidentate ligand). The parameter is empirically derived by assuming that the electronic effect, or contribution, that any given ligand L will add to...
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In: Inorganic Chemistry, 2009, vol. 48, no. 18, p. 8965-8970
The reduction of (Et(4)N)[Re(III)Br(4)(CO)(2)] (1) by 0.5 equiv of tetrakis- dimethylaminoethylene in acetonitrile yields directly the air-stable, 17-electron Re(II) synthon (Et(4)N)(2)[Re(II)Br(4)(CO)(2)] (2) in nearly quantitative yield. The versatility of 2 as a synthon for Re(II) chemistry was demonstrated by substitution reactions of [Re(II)Br(4)(CO)(2)](2-) with different mono-, bi-,...
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In: Future Medicinal Chemistry, 2013, vol. 5, no. 2, p. 175-188
Since the discovery that CO acts as a cytoprotective and homeostatic molecule, increasing research efforts have been devoted to the exploitation of its therapeutic effects. Both endogenous and exogenous CO improves experimental lung, vascular and cardiac injuries and protects against several inflammatory states. The technology is now in place to bring CO to clinical applications, but the use...
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In: RSC Advances, 2021, vol. 11, p. 7511-7520
New synthetic routes to aerobically stable and substitutionally labile α-diimine rhenium(I) dicarbonyl complexes are described. The molecules are prepared in high yield from the cis–cis–trans-[Re(CO)2(tBu2bpy)Br2]− anion (2, where tBu2bpy is 4,4′- di-tert-butyl-2,2′-bipyridine), which can be isolated from the one electron reduction of the corresponding 17-electron complex (1)....
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In: Dalton Transactions, 2018, vol. 47, no. 48, p. 17221–17232
Herein we report the synthesis of a new biomaterial designed for targeted delivery of poorly water-soluble inorganic anticancer drugs, with a focus on colorectal cancer. Diatomaceous earth microparticles derived from marine microalgae were coated with vitamin B12 (cyanocobalamin) as a tumor targeting agent and loaded with the well- known anticancer agents cisplatin, 5-fluorouracil (5-FU), and...
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In: European Journal of Medicinal Chemistry, 2020, vol. 205, p. 112533
We have prepared a series of ten 3-arylcoumarin molecules, their respective fac- [Re(CO)3(bpy)L]+ and fac-[Re(CO)3(L⁀L)Br] complexes and tested all compounds for their antimicrobial efficacy. Whereas the 3-arylcoumarin ligands are virtually inactive against the human-associated pathogens with minimum inhibitory concentrations (MICs) > 150 μM, when coordinated to the fac-[Re(CO)3]+ core,...
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In: The Journal of Physical Chemistry Letters, 2020, vol. 11, no. 13, p. 5037–5043
In this work, cobalamins with different upper axial substituents and a cobalamin derivative with a ring modification were studied using chiroptical spectroscopies, in particular resonance Raman optical activity (RROA), to shed light on the influence of structural modifications on RROA spectra in these strongly chiral systems in resonance with multiple excited states at 532 nm excitation. We...
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