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Phosphatidylserine transport by ORP/Osh proteins is driven by phosphatidylinositol 4-phosphate

Filseck, Joachim Moser von ; Čopič, Alenka ; Delfosse, Vanessa ; Vanni, Stefano ; Jackson, Catherine L. ; Bourguet, William ; Drin, Guillaume

In: Science, 2015, vol. 349, no. 6246, p. 432–436

In eukaryotic cells, phosphatidylserine (PS) is synthesized in the endoplasmic reticulum (ER) but is highly enriched in the plasma membrane (PM), where it contributes negative charge and to specific recruitment of signaling proteins. This distribution relies on transport mechanisms whose nature remains elusive. Here, we found that the PS transporter Osh6p extracted phosphatidylinositol...