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The yeast protein kinase Sch9 adjusts V-ATPase assembly/disassembly to control pH homeostasis and longevity in response to glucose availability

Wilms, Tobias ; Swinnen, Erwin ; Eskes, Elja ; Dolz-Edo, Laura ; Uwineza, Alice ; Essche, Ruben Van ; Rosseels, Joëlle ; Zabrocki, Piotr ; Cameroni, Elisabetta ; Franssens, Vanessa ; Virgilio, Claudio De ; Smits, Gertien J. ; Winderickx, Joris

In: PLOS Genetics, 2017, vol. 13, no. 6, p. e1006835

The evolutionary conserved TOR complex 1 controls growth in response to the quality and quantity of nutrients such as carbon and amino acids. The protein kinase Sch9 is the main TORC1 effector in yeast. However, only few of its direct targets are known. In this study, we performed a genome-wide screening looking for mutants which require Sch9 function for their survival and growth. In this...