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Muscarinic acetylcholine receptor signaling generates OFF selectivity in a simple visual circuit

Qin, Bo ; Humberg, Tim-Henning ; Kim, Anna ; Kim, Hyong S. ; Short, Jacob ; Diao, Fengqiu ; White, Benjamin H. ; Sprecher, Simon G. ; Yuan, Quan

In: Nature Communications, 2019, vol. 10, no. 1, p. 1–16

ON and OFF selectivity in visual processing is encoded by parallel pathways that respond to either light increments or decrements. Despite lacking the anatomical features to support split channels, Drosophila larvae effectively perform visually- guided behaviors. To understand principles guiding visual computation in this simple circuit, we focus on investigating the physiological properties...