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Characterization of FosL1, a plasmid-encoded fosfomycin resistance protein identified in Escherichia coli

Kieffer, Nicolas ; Poirel, Laurent ; Descombes, Marie-Christine ; Nordmann, Patrice

In: Antimicrobial Agents and Chemotherapy, 2020, vol. 64, no. 4, p. -

Fosfomycin is gaining renewed interest for treating urinary tract infections. Monitoring fosfomycin resistance is therefore important in order to detect the emergence of novel resistance mechanisms. Here, we used the Rapid Fosfomycin NP test to screen a collection of extended-spectrum-β-lactamase- producing Escherichia coli isolates from Switzerland and found a fosfomycin- resistant isolate...

Identification of fosa8, a plasmid-encoded fosfomycin resistance determinant from Escherichia coli, and its origin in Leclercia adecarboxylata

Poirel, Laurent ; Vuillemin, Xavier ; Kieffer, Nicolas ; Mueller, Linda ; Descombes, Marie-Christine ; Nordmann, Patrice

In: Antimicrobial Agents and Chemotherapy, 2019, vol. 63, no. 11, p. -

A plasmid-located fosfomycin resistance gene, fosA8, was identified from a CTX-M- 15-producing Escherichia coli isolate recovered from urine. Identification of this gene was obtained by whole-genome sequencing. It encoded FosA8, which shares 79% and 78% amino acid identity with the most closely related FosA2 and FosA1 enzymes, respectively. The fosA8 gene was located on a transferable 50-kb...

Very low prevalence of MCR-1/MCR-2 plasmid-mediated colistin resistance in urinary tract Enterobacteriaceae in Switzerland

Liassine, Nadia ; Assouvie, Laetititia ; Descombes, Marie-Christine ; Dénervaud Tendon, Valérie ; Kieffer, Nicolas ; Poirel, Laurent ; Nordmann, Patrice

In: International Journal of Infectious Diseases, 2016, vol. 51, p. 4–5