Refine my results

Retromer- and WASH-dependent sorting of nutrient transporters requires a multivalent interaction network with ANKRD50

Kvainickas, Arunas ; Orgaz, Ana Jimenez ; Nägele, Heike ; Diedrich, Britta ; Heesom, Kate J. ; Dengjel, Jörn ; Cullen, Peter J. ; Steinberg, Florian

In: J Cell Sci, 2017, vol. 130, no. 2, p. 382–395

Retromer and the associated actin-polymerizing WASH complex are essential for the endocytic recycling of a wide range of integral membrane proteins. A hereditary Parkinson's-disease-causing point mutation (D620N) in the retromer subunit VPS35 perturbs retromer's association with the WASH complex and also with the uncharacterized protein ankyrin-repeat-domain-containing protein 50 (ANKRD50). ...