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Effects of monoamines and antidepressants on astrocyte physiology: implications for monoamine hypothesis of depression

Marathe, Swananda V ; D’almeida, Priyal L ; Virmani, Garima ; Bathini, Praveen ; Alberi, Lavinia

In: Journal of Experimental Neuroscience, 2018, vol. 12, p. -

Major depressive disorder (MDD) is one of the most common neuropsychiatric disorders affecting over one-fifth of the population worldwide. Owing to our limited understanding of the pathophysiology of MDD, the quest for finding novel antidepressant drug targets is severely impeded. Monoamine hypothesis of MDD provides a robust theoretical framework, forming the core of a large jigsaw puzzle, ...