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Risk factors during first 1,000 days of life for carotid intima-media thickness in infants, children, and adolescents: A systematic review with meta-analyses

Epure, Adina Mihaela ; Rios-Leyvraz, Magali ; Anker, Daniela ; Di Bernardo, Stefano ; Costa, Bruno R. da ; Chiolero, Arnaud ; Sekarski, Nicole

In: PLOS Medicine, 2020, vol. 17, no. 11, p. e1003414

The first 1,000 days of life, i.e., from conception to age 2 years, could be a critical period for cardiovascular health. Increased carotid intima-media thickness (CIMT) is a surrogate marker of atherosclerosis. We performed a systematic review with meta- analyses to assess (1) the relationship between exposures or interventions in the first 1,000 days of life and CIMT in infants, children,...