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Asymmetric and distant effects of a unilateral lesion of the primary motor cortex on the bilateral supplementary motor areas in adult macaque monkeys

Contestabile, Alessandro. ; Colangiulo, R. ; Lucchini, Matteo ; Gindrat, Anne-Dominique ; Hamadjida, Adjia ; Kaeser, Mélanie ; Savidan, Julie ; Wyss, A. F. ; Rouiller, Eric M. ; Schmidlin, Eric

In: Journal of Neuroscience, 2018, vol. 38, no. 50, p. 10644–10656

A restricted lesion of the hand area in the primary motor cortex (M1) leads to a deficit of contralesional manual dexterity, followed by an incomplete functional recovery, accompanied by plastic changes in M1 itself and in other cortical areas on both hemispheres. Using the marker SMI-32 specific to pyramidal neurons in cortical layers III and V, we investigated the impact of a focal...