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The CDK inhibitors in cancer research and therapy

Cicenas, Jonas ; Valius, Mindaugas

In: Journal of Cancer Research and Clinical Oncology, 2011, vol. 137, no. 10, p. 1409-1418

The CDK inhibitors in cancer research and therapy

Cicenas, Jonas ; Valius, Mindaugas

In: Journal Of Cancer Research and Clinical Oncology, 2011, vol. 137, no. 10, p. 1409-1418

Chemical compounds that interfere with an enzymatic function of kinases are useful for gaining insight into the complicated biochemical processes in mammalian cells. Cyclin-dependent kinases (CDK) play an essential role in the control of the cell cycle and/or proliferation. These kinases as well as their regulators are frequently deregulated in different human tumors. Aberrations in CDK...