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    Université de Fribourg

    Mms19 promotes spindle microtubule assembly in Drosophila neural stem cells

    Chippalkatti, Rohan ; Egger, Boris ; Suter, Beat

    In: PLOS Genetics, 2020, vol. 16, no. 11, p. e1008913

    Mitotic divisions depend on the timely assembly and proper orientation of the mitotic spindle. Malfunctioning of these processes can considerably delay mitosis, thereby compromising tissue growth and homeostasis, and leading to chromosomal instability. Loss of functional Mms19 drastically affects the growth and development of mitotic tissues in Drosophila larvae and we now demonstrate that...